Table 3. Summary of the Clinical, Cerebrospinal Fluid, and MRI Characteristics of Myelitis With MOG-IgG, AQP4-IgG, and MS.
Characteristics | MOG-IgG | AQP4-IgG | MS |
---|---|---|---|
Clinical/demographic | |||
Female | Frequent | Very frequent | Frequent |
Children | Frequent | Infrequent | Infrequent |
ADEM phenotype | Frequent | Infrequent | Rare |
Severe myelitis (wheelchair dependent) | Frequent | Frequent | Rare |
Excellent recovery | Frequent | Infrequent | Very frequent |
CSF | |||
White blood cell >50/μL | Frequent | Infrequent | Rare |
Positive oligoclonal bands | Infrequent | Infrequent | Very frequent |
MRI spine | |||
Longitudinally extensive T2 lesion(s) | Frequent | Very frequent | Rare |
Short T2 lesion(s) | Frequent | Infrequent | Very frequent |
Gray matter restricted (H sign/sagittal line) | Frequent | Infrequent | Rare |
Axial T2 central | Very frequent | Very frequent | Rare |
Axial peripheral (dorsal/lateral column) | Rare | Rare | Very frequent |
Multiple lesions | Frequent | Rare | Frequent |
Enhancement of myelitis lesion(s) | Infrequent | Frequent | Frequent |
MRI head | |||
Inferior temporal periventricular lesion(s) | Rare | Rare | Frequent |
Deep gray matter lesion(s) | Frequent | Infrequent | Rare |
Gadolinium enhancing lesions | Infrequent | Infrequent | Frequent |
Abbreviations: ADEM, acute disseminated encephalomyelitis; AQP4, aquaporin-4; CSF, cerebrospinal fluid; MOG, myelin oligodendrocyte glycoprotein; MRI, magnetic resonance imaging; MS, multiple sclerosis.
SI conversion factor: To convert white blood cell count to ×109/L, multiply by 0.001.