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. 2018 Dec 21;76(3):301–309. doi: 10.1001/jamaneurol.2018.4053

Table 3. Summary of the Clinical, Cerebrospinal Fluid, and MRI Characteristics of Myelitis With MOG-IgG, AQP4-IgG, and MS.

Characteristics MOG-IgG AQP4-IgG MS
Clinical/demographic
Female Frequent Very frequent Frequent
Children Frequent Infrequent Infrequent
ADEM phenotype Frequent Infrequent Rare
Severe myelitis (wheelchair dependent) Frequent Frequent Rare
Excellent recovery Frequent Infrequent Very frequent
CSF
White blood cell >50/μL Frequent Infrequent Rare
Positive oligoclonal bands Infrequent Infrequent Very frequent
MRI spine
Longitudinally extensive T2 lesion(s) Frequent Very frequent Rare
Short T2 lesion(s) Frequent Infrequent Very frequent
Gray matter restricted (H sign/sagittal line) Frequent Infrequent Rare
Axial T2 central Very frequent Very frequent Rare
Axial peripheral (dorsal/lateral column) Rare Rare Very frequent
Multiple lesions Frequent Rare Frequent
Enhancement of myelitis lesion(s) Infrequent Frequent Frequent
MRI head
Inferior temporal periventricular lesion(s) Rare Rare Frequent
Deep gray matter lesion(s) Frequent Infrequent Rare
Gadolinium enhancing lesions Infrequent Infrequent Frequent

Abbreviations: ADEM, acute disseminated encephalomyelitis; AQP4, aquaporin-4; CSF, cerebrospinal fluid; MOG, myelin oligodendrocyte glycoprotein; MRI, magnetic resonance imaging; MS, multiple sclerosis.

SI conversion factor: To convert white blood cell count to ×109/L, multiply by 0.001.