Table 2. Pathway-Specific Genetic Polymorphisms for Allelic Risk Scores.

Allelic Variant by Pathway	Gene	Chromosome	Variation	Type	Direction of Model Coefficient
Endothelial function pathway
rs12944039	NOS2A	17	A/G	Intron	+
rs2072324	NOS2A	17	A/C	Intron	+
rs2255929	NOS2A	17	A/T	Intron	+
rs1137933	NOS2A	17	C/T	Coding sequence nonsynonymous	−
Metal-processing pathway
rs224572	SLC11A2	12	A/G	Intron	−
rs422982	SLC11A2	12	A/T	Intron	+
rs12227734	SLC11A2	12	A/G	Intron	−
rs1005559	SLC11A2	12	A/T	Intron	−
rs1799945	HFE	6	C/G	Exon	−
Oxidative stress pathway
rs1001179	CAT	11	A/G	Promoter	+
rs480575	CAT	11	C/T	Intron	−
rs2071746	HMOX1	22	A/T	Promoter	+
rs5995098	HMOX1	22	C/G	Intron	+
rs1800566	NQO1	16	C/T	Coding sequence nonsynonymous	+
rs2282679	GC	4	A/C	Intron	−
rs3170633	GCLM	1	A/G	3′ End	−

Abbreviations: +, positive; −, negative.