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. 2017 Jun 29;109(12):djx118. doi: 10.1093/jnci/djx118

Figure 2.

Figure 2.

Concordance of mutation calls between solid and liquid biopsies. A) Bar plot showing the variant allele frequencies for driver mutations in selected clinically relevant metastatic castration-resistant prostate cancer (mCRPC) genes. For each mutation, allele frequencies are provided for the solid tissue biopsy (S) and the cell–free DNA (cfDNA) liquid biopsy (L). The circulating cell-free tumor DNA (ctDNA) fraction corresponding to each mutation is shown in the lower panel. B) Variant allele frequencies for somatic mutations shared between matched liquid and solid biopsies, showing broad conservation of mutant allele fraction hierarchy. ctDNA fraction for each liquid biopsy is provided at the bottom. For patient 149, two cfDNA samples obtained at different time points are shown. AF = allele frequency; ctDNA = circulating cell-free tumor DNA.