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. 2019 Mar 22;11:39. doi: 10.3389/fnagi.2019.00039

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Copyright © 2019 Manno, Isla, Manno, Ahmed, Cheng, Barrios and Lau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FA and RD alterations in 3xTg-Alzheimer’s disease (AD) and control mice. Diffusion tensors are FA, MD, (RD λ⊥), (AD λ//). The grayscale bar indicates the range of values displayed in the DTI parametric maps. The maximum values for FA, λ//, λ⊥ and MD maps are 1.0, 3.0, 2.0, and 3.0 m²/ms, respectively. (A) Representative mouse FA maps (first column of brains from left) and RD λ⊥ maps (second column of brains from left) from individual 3xTg-AD and control mice. (B) Average group maps for 3xTg-AD and control values for FA maps (third column of brains from left) and RD λ⊥ maps (fourth column of brains from left). Note the red outline for FA control in the average group panel represents the approximate ROI for measures. (C) Bar plots of DTI cortical measures: FA, MD, RD λ⊥, and AD λ// for control (blue) and 3xTg-AD (red) with standard deviation. The asterisk ** indicates significant P < 0.01.