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. 2019 Mar 22;11:39. doi: 10.3389/fnagi.2019.00039

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Copyright © 2019 Manno, Isla, Manno, Ahmed, Cheng, Barrios and Lau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ventricular enlargement in 3xTg-AD compared with control mice. Using the RD λ⊥ map of each mouse minimizes partial volume of gray matter (GM) and white matter (WM) structures. (A) The 3xTg-AD group average ventricular enlargement along Bregma −3.0 and −3.8. (B) Bar plot of ventricle size in mm³ along Bregma −3.0, and −3.8 for 3xTg-AD (red) and control (blue). Ventricles were calculated by delineating the RD λ⊥ map of each ventricle to minimize the partial volume of GM and WM structures. The volume (mm³) of ventricles was then determined and compared. The asterisk *** represents highly significant P < 0.001 difference.