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. 2019 Mar 22;11:39. doi: 10.3389/fnagi.2019.00039

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Copyright © 2019 Manno, Isla, Manno, Ahmed, Cheng, Barrios and Lau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The rsfMRI connectivity change in 3xTg-AD compared with controls. (A) SBA in 3xTg-AD and control FC maps of hippocampus (upper panel) and CPu (lower panel) for right and left hemisphere seed. The ROI for hippocampus and CPu were derived from Franklin and Paxinos (2008) overlay Figure 1A. Note significantly reduced FC in left or right seed for 3xTg-AD in the hippocampus, but relatively unchanged for CPu. Color bar represents correlation coefficient from 0.75 yellow to 0.45 red. (B) Bar plots of average FC in hippocampus (upper) and CPu (lower) for the 3xTg-AD (red) and control (blue) groups. Color bar represents correlation coefficient. The asterisk ** indicates highly significant P < 0.01.