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. 2019 Mar 22;11:64. doi: 10.3389/fnagi.2019.00064

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Copyright © 2019 Boutajangout, Lindberg, Awwad, Paul, Baitalmal, Almokyad, Höidén-Guthenberg, Gunneriusson, Frejd, Härd, Löfblom, Ståhl and Wisniewski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental timeline for the treatment strategy of 2xTg Alzheimer’s disease (AD) mice. Timeline showing time points for: (i) breeding of animals with double transgenes amyloid precursor protein (APP_K670N/M671L and PS1_M146V) for vascular amyloid deposition; (ii) pathology development (3 $\frac{1}{2}$ months); (iii) start and duration of preventive treatment with the Aβ-binding Z_SYM73-ABD affibody molecule and control (Z_Taq)₂-ABD; and (iv) behavioral assessment of animals.