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. 2019 Mar 22;11:64. doi: 10.3389/fnagi.2019.00064

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Copyright © 2019 Boutajangout, Lindberg, Awwad, Paul, Baitalmal, Almokyad, Höidén-Guthenberg, Gunneriusson, Frejd, Härd, Löfblom, Ståhl and Wisniewski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cognitive testing and locomotor assessment of the affibody-administered APP/PS1 mice. (A,B) Assessment of sensorimotor abilities in 2xTg mice administered with the Z_SYM73-ABD affibody molecule (red) or control (Z_Taq)₂-ABD (black) in (A) rotarod and (B) open field locomotor tests in which distance traveled, resting time, maximum velocity and average speed of mice were tested. (C) Radial arm maze testing (working memory assessment) of the Z_SYM73-ABD (red) and (Z_Taq)₂-ABD (black) treated 2xTg mice. A group of wild type healthy control mice was included for comparison (blue). Animals were allowed to navigate the maze once per day for nine consecutive days. The number of errors that the mice performed on each testing day is plotted vs. the days of testing (p < 0.0001, by two-way ANOVA for treatment effect).