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. 2019 Mar 22;11:64. doi: 10.3389/fnagi.2019.00064

Figure 4.

Figure 4

Histological evaluation of total amyloid brain burden. Representative immunohistochemical images and quantitative serological analysis of total amyloid burden using Aβ-binding antibodies 6E10/4G8 on brain sections from ZSYM73-ABD (red) or (ZTaq)2-ABD (black) control-treated mice, at 5× magnification (A,D). Amyloid reduction in cortical (46% reduction, *p = 0.03, one-tailed t-test; C,F,H) and hippocampal (37% reduction, **p = 0.008, one-tailed t-test; B,E,G) brain sections at 10× magnification, scale bar (100 μm).