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. 2019 Mar 22;10:237. doi: 10.3389/fphys.2019.00237

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Copyright © 2019 Aguado, Olivares, Yagüe, Silva, Nuñez-García, Fernandez-Quilez, Mill, Genua, Arzamendi, De Potter, Freixa and Camara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Computational workflow to recommend optimal left atrial appendage occlusion (LAAO) settings for a selected patient. The first stage produces LAA morphological measures from LA segmentations obtained on three-dimensional medical images. Computational 3D renderings of LA/LAA geometries are then jointly visualized with morphological measures and Computer-Aided Design models of LAAO devices in the VIDAA platform. The VIDAA platform allows an interactive and individualized virtual implantation of LAAO devices, generating multiple configurations that can be exported for further processing. Computational-Fluid Dynamics (CFD) simulations run on the exported LAAO configurations provide hemodynamics descriptors to estimate the risk of thrombus formation for each case, which are finally reported to clinicians to support their decisions.