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. 2019 Mar 22;10:237. doi: 10.3389/fphys.2019.00237

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Copyright © 2019 Aguado, Olivares, Yagüe, Silva, Nuñez-García, Fernandez-Quilez, Mill, Genua, Arzamendi, De Potter, Freixa and Camara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood flow streamlines in the left atrial appendage (LAA) from hemodynamics simulations of the four patients under study. Snapshots capture the flow behavior in diastole, when higher velocities are present (t = 0.55 s). No LAAO: without device; VIDAA-init: device settings from morphological analysis and clinical recommendations; VIDAA-end: device settings after interactive manipulation in VIDAA; 20% smaller: device with a 20% smaller size than VIDAA-init; Misplaced: device with sub-optimal position and orientation.