Table 3.

Effects of alfaxalone (10 nM–10 μM) on spontaneous glycinergic IPSCs.

Alfaxalone concentration	Amplitude (pA)	Frequency (Hz)	10%–90% rise-time (ms)	Half-width (ms)
Control	−52 (−77 to −28)	1.01 (0.46–2.68)	7.6 (4.2–10.9)	7.2 (3.8–10.7)
10 nM	−47 (−72 to– 22)	1.00 (0.42–2.68)	7.1 (5–9.2)	7.1 (4–10.1)
30 nM	−45.5 (−63 to −28)	0.71 (0.29–2.58)	4.4 (2.9–5.9)	7.1 (3.7–10.5)
100 nM	−45 (−75 to −17)	0.66 (0.12–2.67)	4.4 (3.2–5.5)	6.9 (4.3–9.4)
300 nM	−44 (−58 to −27)	0.64 (0.10–2.3)	4.6 (3.3–5.9)	7 (4.7–9.3)
1 μM	−44 (−52 to −33)	0.57 (0.2–2.22)	4.2 (3.3–5.2)	8 (4.6–11.8)
3 μM	−35 (−44 to −27)	0.44* (0.3–0.88)	6.1 (3.9–8.3)	5.8 (3.8–7.8)
10 μM	−31 (−40 to −21)	0.21* (0.14–0.45)	6.9 (5.4–8.5)	4.8 (2.8–6.9)

Mean ± 95% CI, n = 7 HMNs. Repeated measures ANOVA, Dunnett’s test. *P < 0.05.