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Effects of alfaxalone (25 μM) on miniature glycinergic IPSCs.
| Alfaxalone concentration | Amplitude (pA) | Frequency (Hz) | 10%–90% rise-time (ms) | Half-width (ms) | Iholding (pA) |
|---|---|---|---|---|---|
| Control | −95.5 (−130.4 to −60.6) | 1.97 (1.5–2.4) | 2.4 (1.4–3.5) | 8.6 (5.6–11.3) | −160.6 (−209.4 to −111.7) |
| 25 μM | −43.9 (−56.5 to −31.3) | 1.21 (0.8–1.6) | 3.2 (1.5–4.8) | 7.3 (3.5–11.1) | −104.1 (−133.2 to −75) |
| P = | 0.0014** | 0.0013** | 0.2 | 0.39 | **0.0039 |
Mean and 95% CI, n = 14 HMNs. Paired two tailed t-test. **P < 0.01.
