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. 2019 Mar 22;13:18. doi: 10.3389/fncir.2019.00018

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Copyright © 2019 Khalil, Godde and Karim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic overview of the neurobiology of creativity as outlined in this review. It symbolizes the brain systems and neuromodulatory pathways underlying and modulating creative cognition and creative drive in health and disease. The creative cognition is based on various cognitive functions such as cognitive flexibility, inhibitory control, working memory (WM) updating, fluency, originality, and insights. The creative drive includes several factors that influence creativity such as emotion motivation, reward and other factors such as mood states, regulatory focus, and social interaction. The neuromodulatory pathways include the noradrenergic (NE), the dopaminergic (DA) and the serotonergic (5-HT) pathways.