Table S1.
Comparison of various CSF parameters (N=81)a
| Parameters | TBMb (N=39) | NTIM (N=16) | IND (N=16) | NIND (N=10) | TBM vs NTIM | TBM vs IND | TBM vs NIND |
|---|---|---|---|---|---|---|---|
| Age (years) | 7 (2.75–11) | 6 (1.31–10.35) | 7.5 (4.5–13.25) | 5.5 (1.75–10.5) | – | – | – |
| Cells in CSF (per µL) | 30 (5.5–100) | 55 (15–175) | 0.5 (0–2.75) | 0 (0–2) | P=0.55 | <0.05 P=0.0003 | <0.0001 |
| Number of samples with cells (≥10 per µL) | 28 | 12 | 2 | 3 | – | – | – |
| Lymphocyte % | 75 (24.5–100) | 5 (0–65) | 25 (0–100) | 0 (0–100) | <0.05 P=0.02 |
P=0.25 | P=0.22 |
| Number of samples with lymphocytes (>50%) | 25 | 5 | 7 | 7 | – | – | – |
| Neutrophils | 0 (0–30) | 30 (0–92.5) | 0 (0–0) | 0 (0–0) | P=0.17 | P=0.29 | <0.05 P=0.003 |
| CSF sugar (mg%) | 53 (34.5–66.5) | 54 (25–79.75) | 69.5 (60–77.5) | 62 (48.75–82.25) | P=0.83 | <0.05 P=0.013 |
P=0.14 |
| Concomitant blood sugar | 108 (95.5–121.5) | 111 (108–121) | 100 (91–116.5) | 99.5 (92.75–110.25) | P=0.34 | P=0.51 | P=0.41 |
| CSF to blood sugar ratio | 0.47 (0.32–0.58) | 0.49 (0.19–0.7) | 0.7 (0.58–0.728) | 0.69 (0.43–0.82) | P=0.99 | <0.05 P=0.002 |
<0.05 P=0.02 |
| Number of samples with low CSF to blood sugar ratio (<0.5) | 19 | 8 | 3 | 5 | – | – | – |
| CSF protein (mg%) | 97 (75–136) | 75 (43.5–105.5) | 52 (34.5–77.5) | 32.5 (25.5–62.5) | P=0.06 | <0.05 P=0.002 |
<0.05 P=0.0004 |
| Number of samples with raised CSF proteins (>100 mg/dL) | 18 | 4 | 3 | 2 | – | – | – |
Notes:
a
Median values are indicated; values in brackets indicate the interquartile range. This study was performed on an archived sample from a previous study by Haldar et al.1
b
Includes “definite”, “probable” and “possible” TBM groups.
Abbreviations: TBM, tuberculosis meningitis; NTIM, nontuberculosis infectious meningitis; IND, infectious neurological disorders; NIND, nonIND; CSF, cerebrospinal fluid.