Table 2.
Comparison of SLE patients
| Characteristic | Anti-IL-10 Ab positive (n=14) | Anti-IL-10 Ab negative (n=66) | P-value |
|---|---|---|---|
| Age (years) | 37.7±14.0 | 46.2±13.4 | 0.033 |
| Age at onset (years) | 26.8±14.0 | 34.9±14.2 | 0.066 |
| Duration (years) | 10.9±7.6 | 11.6±8.0 | NS |
| SLEDAI | 6.7±4.8 | 6.6±8.0 | NS |
| NPSLE | 0 (0%) | 2 (3%) | NS |
| Arthritis | 1 (7%) | 7 (11%) | NS |
| Urinary casts | 3 (21%) | 12 (18%) | NS |
| Hematuria | 2 (14%) | 7 (11%) | NS |
| Proteinuria | 3 (21%) | 15 (23%) | NS |
| New rash | 3 (21%) | 8 (12%) | NS |
| Alopecia | 1 (7%) | 3 (5%) | NS |
| Mucosal ulcers | 1 (7%) | 7 (11%) | NS |
| Pleurisy/pericarditis | 1 (7%) | 6 (9%) | NS |
| Low complement | 12 (86%) | 34 (52%) | 0.018 |
| Low C3 | 10 (76%) | 26 (41%) | 0.031 |
| Low C4 | 10 (76%) | 31 (51%) | NS |
| Low CH50 | 3 (100%) | 19 (58%) | NS |
| IgG | 2,019.6±744.3 | 1,391.8±455.0 | 0.001 |
| Increased DNA binding | 7 (50%) | 32 (48%) | NS |
| Fever | 2 (14%) | 8 (12%) | NS |
| Thrombocytopenia | 1 (7%) | 6 (9%) | NS |
| Leukopenia | 2 (14%) | 1 (15.9) | NS |
Notes: Data were analyzed with the Mann–Whitney U test and Fisher’s exact test. Significant differences were observed in low complement and increased serum IgG.
Abbreviations: IgG, immunoglobulin G; NPSLE, neuropsychiatric SLE; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index.