Table 2. Pharmacokinetic parameters of quercetin (Qr), isoquercitrin (IQ), and quercetin-3-O-β-D-glucuronide (QG) after oral administration of 50 mg/kg Qr, IQ, and QG separately in rats.
(Mean ± SD, n = 5).
| Pharmacokinetic parameters | Qr group | IQ group | QG group | ||||
|---|---|---|---|---|---|---|---|
| Qr | QG | IQ | Qr | QG | QG | Qr | |
| AUC0−t (mg/L*min) | 2,590.5 ± 987.9 | 1,150.0 ± 454.2 | 17.2 ± 7.3 | 2,212.7 ± 914.1 | 669.3 ± 188.3 | 962.7 ± 602.3 | 3,505.7 ± 1,565.0 |
| MRT0−t (min) | 383.3 ± 24.3 | 315.9 ± 134.7 | 40.6 ± 7.2 | 422.6 ± 148.6 | 355.9 ± 94.6 | 437.8 ± 36.3 | 491.1 ± 22.6 |
| t1/2z (min) | 437.3 ± 54.3 | 545.8 ± 436.6 | 42.6 ± 27.9 | 378.4 ± 338.8 | 523.5 ± 190.4 | 376.4 ± 95.2 | 365.4 ± 152.1 |
| Tmax (min) | 54.0 ± 25.1 | 42.0 ± 16.4 | 27.0 ± 6.7 | 42.0 ± 16.4 | 30.0 ± 0.0 | 222.0 ± 119.2 | 360 ± 120 |
| CL (L/min/kg) | 0.02 ± 0.008 | 0.043 ± 0.029 | 2.91 ± 1.29 | 0.024 ± 0.011 | 0.07 ± 0.02 | 0.071 ± 0.057 | 0.014 ± 0.014 |
| Cmax (ug/mL) | 7.47 ± 2.63 | 6.46 ± 2.94 | 0.35 ± 0.11 | 6.60 ± 2.67 | 3.91 ± 1.34 | 2.04 ± 0.85 | 5.17 ± 1.85 |
Note:
AUC, the area under concentration-time curve; MRT, mean residence time; t1/2z, half-life; Cmax, maximum plasma concentration; and Tmax, time; CL, clearance rate.