Table 1:

FLG LOF variants and FLG repeat alleles in African American pediatric patients with atopic dermatitis (n=39) reported with respect to human reference FLG 10-repeat allele.

FLG LOF Variant	hg19 coordinate/ RSID (if known)	Location of variant to FLG repeat	FLG repeat allele 1	FLG repeat allele 2	Total # FLG repeats	Age	SCORAD	Asthma	Allergic rhinitis	Food Allergies	Ichthyosis Vulgaris (IV)/ Xerosis (X)
c.488delG¶	chr1:152,286,874	0	10	10	20	7	73	Yes	Yes	Yes1,2,3	IV
p.R501*	rs61816761	1	11	11	22	11	83	Yes	No	None	X
p.R501*	rs61816761	1	10	11	21	13	38	Yes	Yes	None	X
p.R826*	rs115746363	2	10	10	20	5	51	Yes	No	Yes1	X
p.R826*	rs115746363	2	10	10	20	1	65	Yes	No	None	X
p.S3101*¶	chr1:152,278,060	9	10	10	20	10	41	Yes	Yes	None	X
p.S3316*	rs149484917	9	10	11	21	4	50	Yes	No	Yes4	X
p.S3316*	rs149484917	9	10	11	21	2	94	No	No	Yes1	X
p.S3316*	rs149484917	9	10	10	20	0.5	85	No	No	None	X

^¶ denotes novel FLG LOF

¹Peanut

²Shellfish

³Seafood

⁴Eggs

Reports of asthma, allergic rhinitis, and food allergies are in response to our study questionnaire and obtained during medical exam history.