Table 2.

Summary of microRNAs regulating pathophysiology of AAAs

miRNA	Cell types	Potential biomarker	Animal model	miRNA modulation method	Results	Target genes	References
mir-29	SMC EC FB	No	Elastase, AngII, Marfan	Viral OE Anti-miR	Inhibition reduces AAA	collagens elastin	62, 65, 95
miR-21	SMC EC FB	No	Elastase, AngII	Viral OE Anti-miR	OE reduces AAA	PTEN	50
miR-24	SMC EC MPh	Yes	Elastase, AngII	Viral OE Inhibition	OE reduces AAA	CHI3L1	77
miR-33	SMC MPh HC	No	AngII, CCl2	Knockout	Inhibition reduces AAA	ABCA1	78,80
miR-143 miR-145	SMC FB EC	No*	AngII	Viral OE Knockout	OE induces SMC differentiation	KLF4 PHACTR4	83
miR-181b	MPh EC	No	AngII	Anti-miR	Conflicting results	TIMP3 elastin	85–87
miR-195	SMC	Yes	AngII	AntagomiR	Inhibition reduces AAA	collagen proteoglycan elastin SMAD3	68, 89–91
miR-205 miR-712	EC SMC	No	AngII	Anti-miR	Inhibition reduces AAA	TIMP3	57

SMC: Smooth muscle cells, EC: Endothelial cells, FB: Fibroblasts, MPh: Macrophages, HC: Hepatocytes, AngII: Angiotensin II, OE: Overexpression. *miR-143/145 may be useful biomarkers for vascular disease, but not specific for aneurysms.