Fig. 7A-C.

Relative potency of corticosterone (Cort), parent D22, and D22 analogs (C1-C7). A. shows the IC₅₀ ratio for the comparison of hOCT3 to hOCT2 (black, closed circles) and hPMAT (open circles); and B. shows the IC₅₀ potency ratio for the comparison of mSERT to mDAT (open squares) and mNET (black, closed squares). A. The IC₅₀ values, in μM (Table 4), for the competitive inhibition of [³H]MPP⁺ uptake by each compound at hOCT3 were divided by that of hOCT2 (●) or hPMAT (◯) to give a unitless ratio. Ratio values < 1 represent greater uptake inhibition at hOCT3, and values > 1 indicate greater potency at hPMAT or hOCT2. A lower range of the y-axis in depicted since all compounds had a ratio value that did not exceed 1. B. The IC₅₀ values, in μM (Table 2), for each compound to displace [³H]citalopram at SERT were divided by the [³H]WIN 35428 displacement at DAT (⬜) and [³H]nisoxetine binding at NET (■) from mouse brain tissue preparations (as described earlier). For the unitless ratio obtained, values < 1 were more potent at mSERT and >1 more potent at mDAT or mNET. An IC₅₀ ratio value of 1 indicates equipotency of the compound for both transporters of the comparison. A wider range of the y-axis in depicted to reflect the compounds with ratio values greater than 1.