Table 3.

Radioligand uptake inhibition by cocaine, corticosterone, and decynium-22 at mouse DAT, NET, and SERT transiently expressed in HEK cells.

Drug Name	mDAT-HEK IC50 in μM [95% CI] (n)	mNET-HEK IC50 in μM [95% CI] (n)	mSERT-HEK IC50 in μM [95% CI](n)
Cocaine	0.18 aaa [0.095–0.32] (6)	1.18 aaa, bbb [0.8–1.8] (6)	0.51 aaa [0.22–1.16] (6)
Corticosterone	364.6 aaa [154.7–859.4] (6)	839.8 aaa [334–2113] (6)	444.7 aaa [128.6–153.8] (6)
Decynium 22ccc	12.9 [9.8–16.9] (6)	35.0bbb [25–49.2] (6)	7.9 bb [6.4–9.7] (6)

IC₅₀ estimations determined from concentration response curves (Fig. 4) fit to a nonlinear regression.

^aP < 0.05

^aaP < 0.01

^aaaP < 0.001 indicates significance of difference for the drug versus decynium 22 within a cell line.

^bP < 0.05

^bbP < 0.01

^bbbP < 0.001 indicates significance of difference for the compound compared to mDAT

^cccP < 0.001 indicates significant difference between mNET and mSERT.