Table 4.

Transcript-metabolite pairs most strongly associated with TB progression from each significantly enriched KEGG pathway.

	Metabolite	Gene	Model fit AUC	AUC lower 95% CI	AUC upper 95% CI
Lysosome	Mannose	NPC2	0.72	0.66	0.78
Aminoacyl-tRNA biosynthesis	Arginine	WARS	0.7	0.64	0.77
Protein digestion and absorption	Alanine	SLC9A3	0.71	0.65	0.77
Sphingolipid metabolism	Serine	ACER3	0.68	0.62	0.75
Glutathione metabolism	5-oxoproline	LAP3	0.70	0.65	0.78