Table 2.
Baseline Characteristics and Factors Related to Surgical Treatment
| 2005-2008 n = 142 |
2009-2012 n = 244 |
2013-2015 n = 162 |
P-Value | |
|---|---|---|---|---|
| Age, Mean (SD) | 47.0 (15.7) | 47.0 (14.4) | 45.2 (15.2) | .43 |
| Female, n (%) | 73 (51.4) | 108 (44.3) | 64 (39.5) | .12 |
| Tumor Size, n (%) | N = 116 | N = 241 | N = 126 | .73 |
| < 4 cm | 51 (44.0) | 96 (39.8) | 47 (37.3) | |
| 4-6 cm | 46 (39.7) | 95 (39.4) | 50 (39.7) | |
| > 6 cm | 19 (16.4) | 50 (20.7) | 29 (23.0) | |
| MRI Preop, n (%) | 132 (93.6) N = 141 |
236 (96.7) | 157 (96.9) | .25 |
| Main Lobe Involved, n (%) | .19 | |||
| Frontal | 66 (46.5) | 127 (52.0) | 94 (58.0) | |
| Temporal | 40 (28.2) | 56 (23.0) | 28 (17.3) | |
| Parietal | 16 (11.3) | 31 (12.7) | 24 (14.8) | |
| Occipital | 5 (3.5) | 10 (4.1) | 5 (3.1) | |
| Overlapping Sites | 5 (3.5) | 6 (2.4) | 3 (1.9) | |
| Not Specified | 10 (7.0) | 14 (5.7) | 8 (4.9) | |
| Laterality, n (%) | N = 138 | N = 242 | N = 160 | .19 |
| Left | 72 (52.2) | 120 (49.6) | 85 (53.1) | |
| Right | 65 (47.1) | 110 (45.5) | 66 (41.3) | |
| Bilateral | 1 (0.7) | 12 (5.0) | 9 (5.6) | |
| Multifocal, n (%) | 15 (10.6) | 20 (8.2) N = 243 |
23 (14.2) | .16 |
| Asymptomatic, n (%) | 7 (6.1) N = 115 | 20 (8.2) | 10 (6.2) | .66 |
| Focal Deficit, n (%) | 44 (31.7) N = 139 |
92 (38.0) N = 242 |
64 (41.8) N = 153 |
.19 |
| Seizures, n (%) | 79 (68.1) N = 116 |
160 (66.1) N = 242 |
99 (64.7) N = 153 |
.84 |
| ICP Related, n (%) | 26 (22.8) N = 114 |
51 (21.1) N = 242 |
49 (32.0) N = 153 | .04 |
| Performance status, n (%) | N = 140 | N = 238 | N = 157 | .03 |
| 0 | 88 (62.9) | 143 (60.1) | 69 (43.9) | |
| 1 | 28 (20.0) | 62 (26.1) | 48 (30.6) | |
| 2 | 17 (12.1) | 25 (10.5) | 31 (19.7) | |
| 3 | 5 (3.6) | 6 (2.5) | 6 (3.8) | |
| 4 | 2 (1.4) | 2 (0.8) | 3 (1.9) | |
| Weeks from Imaging to Surgery, Median (IQR) | 4 (2-8) | 4 (2-12) | 7 (3-15) | .002 |
| Surgery Performed, n (%) | N = 140 | N = 244 | N = 158 | .08 |
| Biopsy | 50 (35.7) | 63 (25.8) | 41 (25.9) | |
| Resection | 90 (64.3) | 181 (74.2) | 117 (74.1) | |
| Radical Resectiona, n (%) | N = 90 40 (44.4) |
N = 181 97 (53.6) |
N = 117 43 (36.8) |
.02 |
| Histopathology, n (%) | <.001 | |||
| Astrocytoma | 90 (63.4) | 112 (45.9) | 71 (43.8) | |
| Oligoastrocytoma | 35 (24.6) | 19 (7.8) | 22 (13.6) | |
| Oligodendroglioma | 17 (12.0) | 113 (46.3) | 69 (42.6) | |
| Postop Complication, n (%) | 23 (16.2) | 64 (26.2) | 46 (28.4) | .03 |
| Postop New Neurological Deficit, n (%) | 16 (17.8) N = 90 |
38 (16.5) N = 231 |
34 (21.0) N = 162 |
.51 |
| Postop New Seizure, n (%) | 1 (1.1) N = 90 |
5 (2.2) N = 230 |
5 (3.1) N = 162 |
.60 |
| Postop Infection, n (%) | 2 (1.7) N = 115 |
8 (3.5) N = 231 |
4 (2.5) N = 162 |
.63 |
| Postop VTE, n (%) | 2 (1.7) N = 115 |
4 (1.7) N = 231 |
5 (3.1) N = 162 |
.62 |
| Postop Hematoma, n (%) | 6 (5.2) N = 115 |
12 (5.2) N = 231 |
8 (4.9) N = 162 |
.99 |
| Reoperation due to Complication, n (%) | 6 (6.7) N = 90 |
15 (6.5) N = 230 |
7 (4.3) N = 162 |
.61 |
| Neurosurgical Ward, Days (IQR) | 5 (3-7) | 4 (3-6) | 4 (3-6) | .04 |
| Planned Oncological Treatment, n (%) | 51 (86.4) N = 59 |
170 (70.2) N = 242 |
110 (69.6) N = 158 |
.03 |
| 30-Day Mortality, n (%) | 2 (1.4) | 3 (1.2) N = 243 |
2 (1.2) | .99 |
| 1-Year Mortality, n (%) | 23 (16.2) | 25 (10.3) N = 243 |
14 (8.6) | .09 |
Abbreviations: ICP, intracranial pressure; IQR, interquartile range; MRI, magnetic resonance imaging; postop, postoperative; preop, preoperatively; VTE, denotes venous thromboembolism.
aRadical resection according to surgeon or imaging, with imaging being more common in later years.
When data are missing, the actual N is provided in individual cells.