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. Author manuscript; available in PMC: 2019 Mar 29.
Published in final edited form as: Chromosoma. 2018 Mar 29;127(3):291–300. doi: 10.1007/s00412-018-0669-6

Figure 1. Main heterochromatin domains and their distinctive features in mammalian cells.

Figure 1

Constitutive and facultative heterochromatin domains are depicted and their characteristic histone variants, modifications and associated proteins are listed. Although it is not heterochromatin per se, we also consider centromeric chromatin, which is rich in repetitive sequences and surrounded by constitutive heterochromatin domains. CENP: centromere protein, HC: heterochromatin, HP1: heterochromatin protein 1, LAD: lamina-associated domain, NAD: nucleolus-associated domain, PRC2: polycomb repressive complex 2, TRF1/2: telomeric repeat binding factor 1/2.