Table 5.
Viral vectors used in gene therapy for genetic hearing loss studies
| Viral vector | Example | Load | Animal | Route of administration | Reference |
|---|---|---|---|---|---|
| Adenovirus | Ad5-CMV-Atoh1-GFP | Atoh1 | Guinea pig | Cochleostomy (scala media) | [274] |
| Ad5-CMV-Math1.11D | Math1 | Guinea pig | Cochleostomy (scala media) | [275] | |
| Ad28-CMV-GFP + Ad28-GFAP-Atoh1 | Atoh1 | Mouse | Round window (scala tympani) | [278] | |
|
| |||||
| Adeno-associated virus | AAV-mVGLUT3 | VGLUT3 | Mouse | Round window (scala tympani) | [271] |
| AAV8-CMV-whirlin-GFP | WHRN | Mouse | Round window (scala tympani) | [272] | |
| AAV2/Anc80L65.CMV.trunc-harm | USH1C | Mouse | Round window (scala tympani) | [276] | |
| BAAV-β-actin-GFP | β-actin | Rat | Cochleostomy (scala media) | [279] | |
|
| |||||
| Herpes simplex virus | pHSV-blc-2 | BCL2 | Rats | Organ of Corti explants | [280] |
| pHSV-BDNF-LacZ | BDNF | Rat | Spiral ganglia explant | [273] | |
|
| |||||
| Lentivirus | Lenti-HOX-GFP | GFP | Mouse | Round window (scala tympani) | [277] |
| Lenti-WOX-GFP | |||||