Skip to main content
. 2019 Feb 22;6(3):ofz076. doi: 10.1093/ofid/ofz076

Table 3.

Phenotypic Analyses of Patient Isolates

Patient Virology Subtype RAS in Patient Isolates VOX EC50 FC From WT VEL EC50 FC From WT SOF EC50 FC From WT
NS3 NS5A NS5B
1 Novel GT2 ND T24S None 0.58 1.2 NR
2 Novel GT2 ND T24S L31M None 0.66 1.2 NR
3 Novel GT2 ND T24S L31M None ND 22.5 NR
4 Novel GT2 None T24S F28C None 1.09 3.7 NR
5 Novel GT2 None T24S L31M None 1.37 0.125 NR
6 Novel GT2 None F28V L31V M289L 0.29 3.7 NR
7 Novel GT2 None T24S L31M M289L 1.43 0.62 NR
8 Novel GT2 None T24S L31M C92T None No data ND ND
9 Novel GT2 NA T24S L31M None Failed Failed NR
10 Novel GT4 None L30R None 1.42 NR NR
11 Novel GT4 None L30R None 0.36 2 NR
12 Novel GT4 None L30R E237G 1 2 NR
13 Novel GT4 None L28V L30H None 1.25 1 NR
14 Novel GT4 None L30R None ND ND ND
15 Novel GT6 None F28M M289L 1.27 3.33 NR
16 Novel GT6 ND None None ND 0.67 NR
17 Novel GT1 I170V Q30R L31M None ND 1.6 1
18 Novel GT3 ND A30K None ND ND ND
19 Novel GT5 No FG coverage in NS3 Q30S L31M T93S None ND 340 ND

Abbreviations: FC, fold change; FG, full genome sequencing; GT, genotype; NA, not applicable due to low sequence coverage; ND, not done due to sample unavailability; NR, no replication; RAS, resistance-associated substitutions; SOF, sofosbuvir; VEL, velpatasvir; VOX, voxilaprevir; WT, wild-type.