TABLE 2.

Performance estimates of studies^a on blood- and urine-based cfDNA detection of M. tuberculosis by nucleic acid amplification techniques in which the methodological steps are a priori considered suitable for cfDNA isolation and detection^b

Publication first author	Yr	Sample type	TB presentation	HIV positive (%)	Smear positive (%)	Method of TB confirmation	% (no./total no. of samples) of indicating:
							Sensitivity	Specificity
Ushio	2016	Plasma	Pulmonary	0	100	Culture	65 (21/33)	93 (18/19)
							29 (10/33)	100 (19/19)
Click	2018	Plasma	Pulmonary	64	100	Culture and/or Xpert	45 (18/40)	67 (2/3)
Cannas	2008	Urine	Pulmonary	5	95	Sputum smear or culture	79 (34/43)	100 (23/23)
Fortun	2014	Urine	Pulmonary	12	NR	Culture	18 (5/28)	NR
			Extrapulmonary	29	NR		70 (57/82)	NR
Labugger	2017	Urine	Pulmonary	0	60	Culture	64 (7/11)	100 (8/8)
Patel	2017	Urine	Pulmonary	38	33	Culture	43 (75/175)	89 (210/237)

^aSee references 23, 24, 25, 32, 33, and 34.

^bNR, not reported; Xpert, Xpert MTB/RIF assay.