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NS3 replicon vectors for susceptibility testing of GT 1 through 6 patient samples. Restriction sites used for transfer of the NS3 protease region from patient-derived viruses are indicated by arrows. UTR, untranslated region; Pi-Rluc, poliovirus internal ribosome entry site (IRES)-Renilla luciferase; Rluc-Neo, Renilla luciferase-aminoglycoside phosphotransferase (neomycin resistance) fusion protein; EMCV IRES, internal ribosome entry site from encephalomyocarditis virus.
