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Luciferase activity of replicon constructs containing lab strain (hatched fill) or patient-derived (solid fill) NS3 protease regions. (A) Genotype 1b (Con1) vector backbone. (B) Genotype 2a, 2b, and 6a backbones. The background luciferase activity of the NS3 frameshift (inactive) vector is shown in a gray bar.
