TABLE 3.
Diagnostic performance in cases of proven/probable invasive pulmonary aspergillosis versus controlsa
| Role of BALf GM as mycological criterion | No. of cases | Readout | Cutoff (mV) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| BALf GM positive ≥ 1.0 | 79 | Visual | 0.71 (0.60, 0.81) | 0.86 (0.79, 0.92) | 0.77 (0.65, 0.86) | 0.82 (0.75, 0.88) | 5.17 (3.25, 8.22) | 0.34 (0.24, 0.48) | |
| Digital | 16.62 (AUC 0.826) | 0.72 (0.61, 0.82) | 0.86 (0.79, 0.92) | 0.77 (0.66, 0.86) | 0.83 (0.75, 0.89) | 5.26 (3.31, 8.36) | 0.32 (0.22, 0.46) | ||
| BALf GM positive ≥ 0.5 | 91 | Visual | 0.65 (0.54, 0.75) | 0.86 (0.79, 0.92) | 0.78 (0.67, 0.86) | 0.77 (0.69, 0.84) | 4.73 (2.97, 7.54) | 0.41 (0.31, 0.54) | |
| Digital | 16.62 (AUC 0.789) | 0.65 (0.54, 0.75) | 0.86 (0.79, 0.92) | 0.78 (0.67, 0.86) | 0.77 (0.69, 0.84) | 4.73 (2.97, 7.54) | 0.41 (0.31, 0.54) | ||
| BALf GM excluded as mycological criterion | 33 | Visual | 0.76 (0.58, 0.89) | 0.86 (0.79, 0.92) | 0.60 (0.43, 0.74) | 0.93 (0.87, 0.97) | 5.53 (3.41, 8.95) | 0.28 (0.15, 0.52) | |
| Digital | 14.21 (AUC 0.864) | 0.82 (0.65, 0.93) | 0.81 (0.73, 0.88) | 0.54 (0.39, 0.68) | 0.94 (0.88, 0.98) | 4.41 (2.95, 6.60) | 0.22 (0.11, 0.46) |
a
PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; BALf GM, bronchoalveolar lavage fluid galactomannan; AUC, area under the curve.