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. Author manuscript; available in PMC: 2019 Mar 29.
Published in final edited form as: J Comput Aided Mol Des. 2018 May 8;32(6):671–685. doi: 10.1007/s10822-018-0120-3

Fig. 1.

Fig. 1

a CDK8 (green) and Cyclin C (red). b A close-up view of the binding pocket of CDK8. Residues that engage in strong interactions with type-I or type-II ligands are labeled with one-letter amino acid codes and shown in licorice. The yellow and blue ovals roughly encircle the ATP and allosteric binding sites, respectively