Fig. 5.

The effect of 4 mg/ml AAT on IBMIR activation by primary human hepatocytes in the Chandler loop model. 5 × 10⁶ human hepatocytes were added to 6 ml of ABO-matched human whole blood and rotated at 24 rpm at 37 °C for 1 h to mimic portal blood flow. a Platelet count N = 6. b C5b-9 expression N = 6. A Randox high sensitivity X Biochip array was used to measure expression of c IL-1β, d IL-6, e IFN-γ and f IL-1RA, N = 3. *P < 0.05, **P < 0.01, ***P < 0.0001