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. 2019 Mar 29;10:1415. doi: 10.1038/s41467-019-09180-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Genetic analysis of DLBCLs. a Scheme of experimental and analytic workflow. b Overlay of copy number profiles showing cancer-relevant amplifications/deletions in 16 DLBCLs from ITP2-M;Rosa26^PB/+;Blm^m3/m3 (IPB) mice. A zoomed-in view is provided for Chr11, which harbors frequent amplifications (identified in mouse GCB as well as ABC DLBCLs). The minimal amplified region contains—among other genes—the known DLBCL oncogenes Bcl11a and Rel. c Circos plot visualizing transposon insertion data from 42 IPB-DLBCLs. Rings from inward to outward: Insertion density plot for both orientations (shown in blue and green), number of insertions per common insertion site (CIS; dark yellow bars; axis from 0 to 140), number of contributing samples per CIS (red bars; axis from 0 to 40). Top 50 CIS genes are annotated. d Top 50 CIS genes ranked by number of contributing DLBCL samples. Molecular function (determined by literature search) of CIS genes is indicated. Transcription factors constituted the largest functional gene class (n = 15). Compared to the total number of mouse transcription factors (n = 1603), the enrichment for transcription factors among the top 50 CIS genes is highly significant (p = 1.4 10⁻⁵, Fisher’s exact test). Genes present in Cancer Gene Census (CGC) database and/or known for their role in DLBCL (literature search) are represented in dark blue, unknown DLBCL genes by light blue boxes. QiSeq quantitative transposon insertion site sequencing, aCGH array comparative genomic hybridization