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. 2019 Mar 29;10:1415. doi: 10.1038/s41467-019-09180-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — CIS genes are significantly downregulated in human DLBCL. Volcano plot shows negatively (left) and positively (right) regulated genes in human DLBCL samples relative to non-malignant B cells (centroblasts) (GSE12453). Gray lines indicate log₂ fold changes of −0.8 and 0.8. Dark blue colored points represent human orthologues of genes from the top 50 CIS list that are included in the Cancer Gene Census (CGC) database and/or have already implicated roles in DLBCL. Light blue colored points depict candidate genes with unknown function in DLBCL