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. 2019 Mar 29;10:1415. doi: 10.1038/s41467-019-09180-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Clinical relevance of CIS genes in human DLBCL. Association of CIS genes with overall and progression-free survival in a large clinically annotated DLBCL patient cohort (n = 424; GSE31312). For each of the 50 CIS genes, the cohort was stratified into "low" (LE; below median expression) or "high" expression (HE, above median). Kaplan–Meier plots for the top five genes, for which associations (between low gene expression and poor survival) were also observed in a second DLBCL patient cohort (n = 220; GSE10846), are shown. The significance threshold was set to a false discovery rate of 0.05. For genes, for which multiple probes were available, the one giving the signal with the highest variance was selected. Association with overall survival (OS) is shown on the top, and association with progression-free survival (PFS) on the bottom