Table 3.
Multivariable Cox regression analysis*: Women diagnosed with different cancers types vs. non-cases**.
| Factors | Respiratory Cancers | GI Cancers | Breast Cancer | FGO Cancers | Other Cancers |
|---|---|---|---|---|---|
| HR (95% CI); P-value; [n, cases] | HR (95% CI); P-value; [n, cases] | HR (95% CI); P-value; [n, cases] | HR (95% CI); P-value; [n, cases] | HR (95% CI); P-value; [n, cases] | |
| BMI | |||||
| Q1 | (ref); [44,930] | (ref); [47,933] | (ref); [33,919] | (ref); [22,909] | (ref); [35,921] |
| Q2 | 0.52 (0.30–0.88); 0.02; [908, 22] | 0.88 (0.58–1.34); 0.55; [933, 47] | 0.98 (0.60–1.61); 0.93; [920, 34] | 0.82 (0.45–1.50); 0.53; [910, 24] | 1.24 (0.79–1.95); 0.35; [935, 49] |
| Q3 | 0.54 (0.31–0.93); 0.03; [887, 23] | 1.23 (0.82–1.84); 0.31; [930, 66] | 1.27 (0.78–2.08); 0.33; [906, 42] | 0.59 (0.31–1.12); 0.11; [883, 19] | 0.73 (0.44–1.24); 0.25; [893, 29] |
| Q4 | 0.39 (0.21–0.73); 0.003; [869, 17] | 0.77 (0.49–1.22); 0.26; [894, 42] | 1.63 (1.00–2.64); 0.05; [905, 53] | 0.83 (0.45–1.53); 0.55; [882, 30] | 0.84 (0.50–1.40); 0.49; [887, 35] |
| Recreational walking | |||||
| (<5 times/week) | (ref); [36,979] | (ref); [59,1002] | (ref); [44,987] | (ref); [26,969] | (ref); [45,988] |
| (≥5 times/week) | 0.77 (0.51–1.17); 0.22; [2615, 70] | 0.92 (0.68–1.26); 0.61; [2688, 143] | 0.96 (0.68–1.37); 0.82; [2663, 118] | 1.00 (0.63–1.59); 1.00; [2614, 69] | 0.81 (0.57–1.17); 0.26; [2648, 103] |
| Exercise habits | |||||
| (<1 time/week) | (ref); [43,1082] | (ref); [62,1001] | (ref); [41,1080] | (ref); [35,1074] | (ref); [48,1087] |
| (≥1 time/week) | 0.74 (0.49–1.10); 0.13; [2512, 63] | 1.00 (0.73–1.35); 0.98; [2589, 140] | 1.27 (0.88–1.82); 0.20; [2570, 121] | 0.68 (0.44–1.04); 0.08; [2509, 60] | 0.88 (0.62–1.26); 0.49; [2549, 100] |
| Education | |||||
| School (9 yrs) | (ref); [80,2570] | (ref); [141,2631] | (ref); [116,2606] | (ref); [74,2564] | (ref) [106,2596] |
| High school (12 yrs) | 0.91 (0.56–1.49); 0.72; [777, 21] | 1.02 (0.72–1.44); 0.92; [798, 42] | 1.04 (0.71–1.52); 0.84; [792, 36] | 0.68 (0.39–1.19); 0.18; [771, 15] | 0.90 (0.59–1.36, 0.61) [785, 29] |
| University (17 yrs) | 0.65 (0.26–1.62); 0.35; [247, 5] | 1.24 (0.76–2.03); 0.38; [261, 19] | 0.84 (0.44–1.61); 0.60; [252, 10] | 0.78 (0.34–1.82); 0.57; [248, 6] | 1.10 (0.61–1.97, 0.76) [255, 13] |
| Smoking | |||||
| Never | (ref); [9,1709] | (ref); [83,1783] | (ref); [78,1778] | (ref); [51,1751] | (ref); [73,1777] |
| Former | 6.30 (2.90–13.66); <0.0001; [1057, 33] | 1.41 (1.03–1.93); 0.03; [1099, 75] | 1.07 (0.75–1.52); 0.72; [1077, 53] | 1.04 (0.67–1.61); 0.86; [1058, 34] | 1.13 (0.79–1.62); 0.51; [1075, 51] |
| Current | 15.28 (7.26–32.13; <0.0001; [828, 64] | 1.37 (0.94–1.99); 0.10; [808, 44] | 1.03 (0.67–1.58); 0.89; [795, 31] | 0.45 (0.23–0.89); 0.02; [774, 10] | 0.79 (0.50–1.27); 0.33; [788, 24] |
| Childbirth | |||||
| (<1 child) | (ref); [13,373] | (ref); [24,384] | (ref); [18,378] | (ref); [10,370] | (ref); [23,383] |
| (≥1 child) | 0.86 (0.48–1.55); 0.62; [3221, 93] | 0.91 (0.59–1.41); 0.68; [3306, 178] | 0.91 (0.56–1.50); 0.72; [3272, 144] | 0.96 (0.50–1.86); 0.90; [3213, 85] | 0.67 (0.42–1.05); 0.08; [3253, 125] |
| Alcohol | |||||
| (<7 units/week) | (ref); [67,2412] | (ref); [133,2478] | (ref); [101,2446] | (ref); [67,2412] | (ref); [102,2447] |
| (≥7 units/week) | 1.03 (0.69–1.54); 0.89; [1182, 39] | 1.04 (0.77–1.41); 0.78; [1212, 69] | 1.33 (0.96–1.84); 0.09; [1204, 61] | 0.92 (0.58–1.44); 0.70; [1171, 28] | 0.92 (0.65–1.32); 0.65; [1189, 46] |
| Central Obesity | |||||
| Q1 | (ref); [28,930] | (ref); [38,940] | (ref); [35,937] | (ref); [16,918] | (ref); [34,936] |
| Q2 | 1.02 (0.57–1.85); 0.94; [902, 20] | 1.36 (0.88–2.11); 0.16; [933, 51] | 1.04 (0.64–1.66); 0.89; [922, 40] | 1.24 (0.63–2.45); 0.54; [902, 20] | 1.08 (0.66–1.76); 0.76; [918, 36] |
| Q3 | 1.07 (0.58–1.97); 0.82; [886, 21] | 1.56 (1.01–2.41); 0.04; [923, 58] | 0.96 (0.59-1.57); 0.88; [903, 38] | 1.93 (1.01–3.70); 0.05; [895, 30] | 1.16 (0.71–1.91); 0.55; [901, 36] |
| Q4 | 2.01 (1.17–3.47), 0.01; [876, 37] | 1.55 (0.99–2.41); 0.05; [894, 55] | 1.26 (0.79–2.03); 0.33; [888, 49] | 1.95 (1.00–3.78); 0.05; [868, 29] | 1.41 (0.87–2.31); 0.17; [881, 42] |
*Analysis was conducted on complete datasets: Respiratory cancers, n = 3594, cases = 106, GI cancers, n = 3690, cases = 202, Breast cancer, n = 3650, cases = 162, FGO cancers, n = 3583, cases = 95, Other cancer, n = 3636, cases = 148.
**Women with no history of cancer.
Abbreviations: GI, Gastrointestinal; FGO, Female Genital Organs; BMI, Body Mass Index.