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. 2019 Mar 29;9:5348. doi: 10.1038/s41598-019-41866-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NPsFA-A1411/DOX/a221 nanoparticles sensitize leukemia cells that are resistant to chemotherapy. (A) CCK-8 assays measuring proliferation of K562DR or (B–D) three primary cells derived from AML patients experiencing chemoresistant relapse and treated with the indicated nanoparticles for 24 hours, followed by incubation with different doses of doxorubicin for an extra 48 hours. Data represent 3 independent experiments, each conducted in triplicate.