Table 2.
Association of three SNPs with GDM risk.
| Genotype | Cases (N = 964)a | Controls (N = 1021)a | Adjusted OR | P c |
|---|---|---|---|---|
| N | N | (95% CI)c | ||
| rs10830962 (C > G) | ||||
| CC | 278 | 316 | 1.00 | |
| CG | 468 | 504 | 1.07 (0.87–1.32) | 0.518 |
| GG | 206 | 182 | 1.36 (1.04–1.76) | 0.022 |
| Dominant model | ||||
| CC | 278 | 316 | 1.00 | |
| CG/GG | 674 | 686 | 1.15 (0.94–1.40) | 0.175 |
| Recessive model | ||||
| CC/CG | 746 | 820 | 1.00 | |
| GG | 206 | 182 | 1.30 (1.04–1.63) | 0.023 |
| Additive model | — | — | 1.16 (1.02–1.31) | 0.029 |
| rs1470579 (A > C) | ||||
| AA | 507 | 546 | 1.00 | |
| AC | 371 | 401 | 0.97 (0.80–1.17) | 0.742 |
| CC | 71 | 52 | 1.42 (0.97–2.09) | 0.073 |
| Dominant model | ||||
| AA | 507 | 546 | 1.00 | |
| AC/CC | 442 | 453 | 1.02 (0.85–1.22) | 0.824 |
| Recessive model | ||||
| AA/AC | 878 | 947 | 1.00 | |
| CC | 71 | 52 | 1.44 (0.99–2.10) | 0.057 |
| Additive model | — | — | 1.07 (0.93–1.24) | 0.349 |
| rs7754840 (G > C) | ||||
| GG | 310 | 353 | ||
| GC | 449 | 461 | 1.09 (0.89–1.33) | 0.420 |
| CC | 185 | 182 | 1.15 (0.89–1.50) | 0.284 |
| Dominant model | ||||
| GG | 310 | 353 | 1.00 | |
| GC/CC | 634 | 643 | 1.11 (0.91–1.34) | 0.302 |
| Recessive model | ||||
| GG/GC | 759 | 814 | 1.00 | |
| CC | 185 | 182 | 1.10 (0.87–1.38) | 0.429 |
| Additive model | — | — | 1.08 (0.95–1.22) | 0.262 |
aMajor homozygote/heterozygote/minor homozygote.
bMAF, minor allele frequency among controls.
cAdjusted by age, prepregnancy BMI, parity, abnormal pregnancy history and family history of diabetes.