Table 3.
Stratified analysis of rs10830962 genotypes associated with GDM risk.
| Variables | rs10830962 (CC/CG/GG) | Adjusted OR | P for | |
|---|---|---|---|---|
| Casesa | Controlsa | (95% CI)b | heterogeneity | |
| Age (year) | ||||
| <35 | 240/401/175 | 277/444/163 | 1.15 (1.00–1.32) | 0.643 |
| ≥35 | 38/67/31 | 39/60/19 | 1.26 (0.88–1.81) | |
| Prepregnancy BMI (kg/m2) | ||||
| Underweight, 18.5 | 19/39/24 | 31/46/22 | 1.37 (0.90–2.07) | 0.855 |
| Normal weight, 18.5–23.9 | 189/326/135 | 207/353/117 | 1.16 (0.98–1.36) | |
| Overweight, 24.0–27.9 | 57/85/40 | 66/94/36 | 1.11 (0.83–1.49) | |
| Obese, ≥28 | 13/18/7 | 12/11/7 | 1.05 (0.53–2.10) | |
| Parity | ||||
| Nulliparous | 234/400/181 | 295/469/170 | 1.17 (1.02–1.34) | 0.348 |
| Multiparous | 44/68/25 | 21/35/12 | 0.93 (0.59–1.48) | |
| Abnormal pregnancy history | ||||
| No | 237/406/192 | 303/486/174 | 1.18 (1.03–1.35) | 0.255 |
| Yes | 41/62/14 | 13/18/8 | 0.83 (0.46–1.50) | |
| Family history of diabetes | ||||
| No | 225/388/167 | 275/432/152 | 1.19 (1.03–1.37) | 0.183 |
| Yes | 53/80/39 | 41/72/30 | 0.94 (0.69–1.30) | |
aMajor homozygote/heterozygote/minor homozygote.
bAdjusted by age, prepregnancy BMI, parity, abnormal pregnancy history and family history of diabetes except for the stratified factor.