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. 2019 Mar 29;10:1407. doi: 10.1038/s41467-019-09190-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Model showing the regulation of RAD51 assembly by SWSAP1 and FIGNL1. (Right) FIGNL1 promotes the dissociation of RAD51 filament to prevent inappropriate HR. FIGNL1 binds to RAD51 through its conserved FxxA motif and facilitates RAD51 dissociation by inducing the conformational change of RAD51 or enhancing ATP hydrolysis of RAD51. (Left) SWSAP1 stabilizes RAD51 filament from anti-recombinase FIGNL1. SWSAP1 binds to RAD51 filament through its conserved FxxA motif. SWSAP1 interacts with FIGNL1 through C-terminus and inhibits FIGNL1’s RAD51-filament disruption activity in the solution and/or at the end of ssDNA