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. 2019 Mar 29;9:5314. doi: 10.1038/s41598-019-41761-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Su(Hw) binding sites are required for repression of transcription. (a) Scheme of the constructs (drawn not to scale) containing the mini white gene (white), LacZ-GFP coding region (LacZ-GFP), transcription terminator from SV40 virus (SV40), and promoters of two model genes, mAcR-60C and Rph (promoter). Arrowheads show the direction of transcription. The sizes of promoter fragments cloned into the constructs are indicated. WT, wild-type sequences including Su(Hw) binding site (bold type); mut, sequences with mutation in Su(Hw) binding site. (b) Expression of two model genes in the wild-type (wt) and mutant (mut) backgrounds. (c) Expression of model genes in the heads in the Su(Hw) overexpression background. Expression levels are shown as a fold change relative to wild type. Error bars indicate standard deviation of two independent biological replicates.