Fig. 2.

L. loa microfilariaemias can be established in immunocompetent and immunocompromised mice. a Time-course of peripheral microfilariaemias in CB.17 SCID (n = 12), BALB/c WT adult splenectomised (spl.), n = 14 or BALB/c WT, n = 8 mice, 2–8 days following infusion with 40,000 purified L. loa mf. Plotted are mean ± SEM of time course data. b Level of L. loa microfilariaemia in cardiac blood in CB.17 SCID, n = 13, BALB/c WT spl., n = 13 or BALB/c WT, n = 15 mice 7 days post infusion with 40,000 purified L. loa mf. Plotted are individual data and means ± SEM. c Level of L. loa microfilariaemia in cardiac blood in groups of n = 4–8 CB.17 SCID microfilaraemic mice, evaluated at between 2 and 8 days following infusion with 40,000 purified L. loa mf. Plotted are individual data and means ± SEM. All data are derived from a single individual experiment (c) or pooled from two experiments (a, b). Significant differences are determined by one-way ANOVA with Dunnett’s post-hoc tests for >2 groups of log-transformed data (a, b) or Kruskal–Wallis with Dunn’s post-hoc tests, per time point (c). Significance is indicated: *p < 0.05, **p < 0.01, ***p < 0.0001, nd not different