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. 2019 Mar 29;9:5361. doi: 10.1038/s41598-019-41779-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nerve profiles are more abundant close to the bone surface. In the bone marrow, nerve and cluster profiles were quantified within and above 100 µm of the bone surfaces. (a,d) The density of PGP9.5+ (a) and TH+ (d) nerve profiles was significantly higher close to the bone surface. (b,e) The density of cluster profiles innervated by PGP9.5+ (b) and TH+ (e) nerve profiles was significantly higher close to the bone surface, indicating that innervated vascular structures are more abundant close to the bone surface compared to the distant bone marrow. (c,f) No difference was observed in the nerve profile/cluster profile ratio of the PGP9.5+ (c) and TH+ (f) innervation, indicating that the increase in innervation was not due to an increase in numbers of nerve profiles per vascular structure. The data was analyzed by clustered regression analysis. ***p < 0.001, n = 11. TH: tyrosine hydroxylase, PGP9.5: protein gene product 9.5.