Fig. 3. The model of transcription factors in the context of lysine methylation in tumorigenesis.

A summary from the current literature of the comprehensive and dynamic methylation processes of transcription factors is depicted in the following models, including of p53 a, RB b, RelA c, STAT3 d, ERα e, RORα f, and AR g. Post-translational modifications at specific sites of activate (in blue) and inactivate (in red) transcription factors, thereby affecting regulation of target gene expression specific for cellular biological processes associated with cancer