Table 2.
Z-Drug Misuse-, Abuse-, Dependence-, Withdrawal-, and Overdose-Related ADRs; PRR Computation
| Zaleplon ADRs | No of reactions ADRs | Proportion of zaleplon ADRs |
|---|---|---|
| Drug abuser (A1) + drug diversion (A2) + drug use disorder (A3) + intentional product use issue (A4) + intentional product misuse (A5) + prescription drug used without prescription (A6) + product use in unapproved indication (A7) + product use issue (A8) + substance abuser (A9) + substance use disorder (A10) | 367 | 0.089 |
| Dependence (A11) | 5 | 0.001 |
| Withdrawal syndrome (A12) + drug withdrawal syndrome (A13) + drug withdrawal headache (A14) + drug withdrawal (A15) | 89 | 0.023 |
| Intentional overdose (A16) + overdose (A17) | 76 | 0.019 |
| Other adverse events (B) | 3733 | 0.868 |
| Total | 4270 | 1.000 |
| Zopiclone ADRs | No of reactions ADRs | Proportion of zopiclone ADRs |
| Drug abuser (C1) + drug diversion (C2) + drug use disorder (C3) + intentional product use issue (C4) + intentional product misuse (C5) + prescription drug used without prescription (C6) + product use in unapproved indication (C7) + product use issue (C8) + substance abuser (C9) + substance use disorder (C10) | 2507 | 0.043 |
| Dependence (C11) | 138 | 0.002 |
| Withdrawal syndrome (C12) + drug withdrawal syndrome (C13) + drug withdrawal headache (C14) + drug withdrawal (C15) | 718 | 0.013 |
| Intentional overdose (C16) + overdose (C17) | 5920 | 0.096 |
| Other adverse events (D) | 55 857 | 0.846 |
| Total | 65 140 | 1.000 |
| Zolpidem ADRs | No of reactions ADRs | Proportion of zolpidem ADRs |
| Drug abuser (E1) + drug diversion (E2) + drug use disorder (E2) + intentional product use issue (E4) + intentional product misuse (E5) + prescription drug used without prescription (E6) + product use in unapproved indication (E7) + product use issue (E8) + substance abuser (E9) + substance use disorder (E10) | 9744 | 0.050 |
| Dependence (E11) | 423 | 0.002 |
| Withdrawal syndrome (E12) + drug withdrawal syndrome (E13) + drug withdrawal headache (E14) + drug withdrawal (E15) | 2433 | 0.018 |
| Intentional overdose (E16) + overdose (E17) | 10 820 | 0.056 |
| Other adverse events (F) | 182 895 | 0.874 |
| Total | 206 315 | 1.000 |
Abbreviations: ADR, adverse drug reaction; PRR, proportional reporting ratio.