Table 1.
Patient Characteristics
| Serum Samples (Set 1) | CSF Samples (Set 2) | MDD Set1 vs Set2 | |||||
|---|---|---|---|---|---|---|---|
| MDD at Pre-ECT | Controls | P value | MDD | Controls | P value | ||
| (n = 37) | (n = 47) | (n = 26) | (n = 27) | P value | |||
| Gender (female) | 22 (59.5%) | 28 (59.6%) | 0.991a | 13 (50.0%) | 13 (48.2%) | 0.893a | .457c |
| Age (years) | 58.7 ± 13.2 | 58.9 ± 11.4 | 0.953b | 41.2 ± 7.3 | 41.9 ± 9.1 | 0.689b | <.001d |
| Age of onset (years) | 53.9 ± 14.2 | 30.2 ± 10.6 | <.001d | ||||
| Duration of current episode (months) | 5.7 ± 6.2 | ND | – | ||||
| Psychotic features | 15 (40.5%) | ND | – | ||||
| Catatonic features | 7 (18.9%) | ND | – | ||||
| Number of episodes | 1.5 ± 1.9 | 1.9 ± 1.2 | .168d | ||||
| Number of ECT sessions per course | 10.0 ± 3.5 | ND | – | ||||
| Total HDRS | 24.4 ± 8.3 | 11.8 ± 7.1 | <.001d | ||||
| IMI equivalence (mg/d) | 225.4 ± 151.6 | 207.8 ± 109.6 | .923d | ||||
Abbreviations: CSF, cerebrospinal fluid; ECT, electroconvulsive therapy; HDRS, Hamilton Depression Rating Scale-17; IMI, imipramine; MDD, major depressive disorder; ND, not detected.
Serum samples (Set 1) and CSF samples (Set 2) were collected from separate facilities. Data shown as either mean ± SD or number (n) and percent of total (%).
aComparison between MDD and control group by chi-square test.
bComparison between MDD and control group by Mann-Whitney U-test.
cComparison between MDD in Set 1 and Set 2 by chi-square test.
dComparison between MDD in Set 1 and Set 2 by Mann-Whitney U-test.