Table 2.
Multivariate Linear Regression Analyses Between Serum and CSF ATX Levels, Diagnosis
| Serum ATX at Pre-ECT (Set 1) | CSF ATX (Set 2) | |||||
|---|---|---|---|---|---|---|
| Nonstandardized Coefficient β | (95% CI) | P value | Nonstandardized Coefficient β | (95% CI) | P value | |
| Constant | 227.034 | (212.535–241.534) | <.001* | 289.670 | (275.585–303.754) | <.001* |
| Diagnosis (control = 0/MDD = 1) | -30.998 | (-49.598 –-12.397) | .001* | -17.186 | (-33.350–-1.022) | .038* |
| Gender (female = 0/male = 1) | -61.606 | (-80.419–-42.793) | <.001* | -23.599 | (-39.763–7.435) | .005* |
| R2 = 0.398, P < .001 | R2 = 0.205, P = .003 | |||||
Abbreviations: CSF, cerebrospinal fluid; ATX, autotaxin; MDD, major depressive disorder. Serum samples (Set 1) and CSF samples (Set 2) were collected from separate facilities. The horizontal bars represent the mean values adjusted for gender. *P < .05.