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. 2019 Jan 11;22(4):303–316. doi: 10.1093/ijnp/pyz001

Figure 2.

Figure 2.

Methamphetamine (METH) exposure during adolescence regulated glycogen synthase kinase 3 beta (GSK3β) phosphorylation patterns and increased GSK3β activity in the medial prefrontal cortex (mPFC) and dorsal hippocampus (dHIP). Representative immunoblot images for mPFC are shown in A. Compared with the control, METH exposure did not alter the ratio of pGSK3β-Y216 to t-GSK3β (B) but decreased the ratio of pGSK3β-S9 to t-GSK3β (C) in the adolescent mPFC, with no significant changes in the relative expression of t-GSK3β (D). Representative immunoblot images for dHIP are shown in E. Compared with the control, METH exposure increased the ratio of pGSK3β-Y216 to t-GSK3β (F) and decreased the ratio of pGSK3β-S9 to t-GSK3β (G) in the adolescent dHIP, with no significant changes in the relative expression of t-GSK3β (H). Data are expressed as the mean ± SEM; n = 12/group; *P < .05 and **P < .01, comparison between the 2 indicated groups; unpaired t tests.