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. 2019 Mar 30;18:55. doi: 10.1186/s12943-019-0965-7

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Role of the extracellular vesicles-mediated intercommunication in tumor development and progression. Tumor and stromal cells release extracellular vesicles as a mean of communication contributing to the complexity and heterogeneity of the tumor microenvironment. Extracellular vesicles-mediated transport of bioactive materials can induce a tumor microenvironment favorable for tumor growth and resistance to anti-cancer drugs