Table 1.
Extracellular vesicles miRNA cargo and chemoresistance in different cancers
| Cancer | Anti-cancer drugs | Cell lines | miRNA cargo | Mechanism | Reference |
|---|---|---|---|---|---|
| Lung | Cisplatin | A549/A549-DDP | ↓ miR-100-5p | horizontal transfer | [133] |
| Lung | Gemcitabine | A549/A549-GR | ↑ miR-222-3p | horizontal transfer | [134] |
| Lung | Cisplatin | A549/H1299 | ↑ miR-96 | horizontal transfer | [135] |
| Lung | Cisplatin | A549/A549-DDP | ↓ miR-146a-5p | horizontal transfer | [136] |
| Breast | Docetaxel | MCF-7 | ↑ miR-100, miR-222, miR-30a, miR-17 | horizontal transfer | [137] |
| Breast | Tamoxifen | MCF-7 | ↑ miR-221/222 | horizontal transfer | [138] |
| Breast | Cisplatin 17-AAG PU-H71 |
Hs578Ts | ↓ miR-134 | horizontal transfer | [139] |
| Breast | Doxorubicin Paclitaxel |
MCF-7/MDA-MB-231 | ↑ miR-155 | horizontal transfer | [140] |
| Breast | Docetaxel Epirubicin Gemcitabine |
MDA-MB-231/HMLE | ↑ miR-1246 | horizontal transfer | [141] |
| Breast | Adriamycin | MCF-7/MCF-7-Adr | ↑ miR-222 | horizontal transfer | [142] |
| Oral cavity | Cisplatin | HSC-3/HSC-3R SCC-9/SCC-9R |
↑ miR-21 | horizontal transfer | [143] |
| Melanoma | Vemurafenib (PLX4032) |
MML-1/MML-1R A375 PDX |
↑ miR-211–5p | Autocrine | [144] |
| Glioblastoma | Temozolomide | SHG-44/U87MG | ↑ miR-221 | horizontal transfer | [145] |
| Prostate | Docetaxel | 22Rv1/22Rv1RD DU145/DU145RD PC3/PC3RD |
↓ miR-34a | horizontal transfer | [146] |
| Colon | Fluorouracil (5-FU) |
DLD-1/DLD-1-5-FU | ↑ miR-145, miR-34a | expulsion | [113] |
| Pancreas | Gemcitabine | Panc1/Panc1-GR | ↑ miR-155 | horizontal transfer | [147] |
| Leukemia | Imatinib | K562/K562-G01 | ↑ miR-365 | horizontal transfer | [148] |
| Leukemia | Daunorubicin | HL60/HL60AR | ↑ miR-196, miR20a | expulsion | [114] |